Metabolism, longevity and epigenetics
نویسندگان
چکیده
منابع مشابه
Genetics and epigenetics of aging and longevity
Evolutionary theories of aging predict the existence of certain genes that provide selective advantage early in life with adverse effect on lifespan later in life (antagonistic pleiotropy theory) or longevity insurance genes (disposable soma theory). Indeed, the study of human and animal genetics is gradually identifying new genes that increase lifespan when overexpressed or mutated: gerontogen...
متن کاملInformation -sharing, adaptive epigenetics and human longevity
Emerging empirical and theoretical thinking about human aging places considerable value upon the role of the environment as a major factor which can promote prolonged healthy longevity. Our contemporary, ‘information-rich’ environment is taken to mean not merely the actual physical surroundings of a person but it is also considered in a more abstract sense, to denote cultural, societal and tech...
متن کاملMetabolism & epigenetics
Epigenetic regulation of gene activity is of immense importance in maintaining normal and dynamic transcription profiles of practically all cells in our body. In the meantime, cells metabolize nutrients to sustain through different tasks and challenges of life. Both metabolism and gene activity respond to changes in environment. By assessing the relative abundance of certain key compounds centr...
متن کاملBridging epigenetics and metabolism
Recent research suggests that chromatin-modifying enzymes are metabolic sensors regulating gene expression. Epigenetics is linked to metabolomics in response to the cellular microenvironment. Specific metabolites involved in this sensing mechanism include S-adenosylmethionine, acetyl-CoA, alphaketoglutarate and NAD (+) . Although the core metabolic pathways involving glucose have been emphasize...
متن کاملEpigenetics and Cellular Metabolism
Living eukaryotic systems evolve delicate cellular mechanisms for responding to various environmental signals. Among them, epigenetic machinery (DNA methylation, histone modifications, microRNAs, etc.) is the hub in transducing external stimuli into transcriptional response. Emerging evidence reveals the concept that epigenetic signatures are essential for the proper maintenance of cellular met...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2013
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-013-1295-3